Is the triglyceride content inside your LDL particles (eLDL-TG) the best indicator for heart disease?
According to this paper: An equation for estimating low-density lipoprotein-triglyceride content and its use for cardiovascular disease risk stratification by Anna Wolska, Maureen Sampson, Rafael Zubir, Jeff W. Meeusen, Leslie J. Donato, Allan S. Jaffe, and Alan T. Remaley, the estimated triglyceride content in low-density lipoprotein particles (eLDL-TG) was a better predictor of risk than their cholesterol content. "Compared to estimated LDL-C, eLDL-TG was a better risk marker for primary prevention and hence could improve initial ASCVD risk stratification."Here is their equation:
${eLDL–TG} ≡ {TG}/38.5 + {NonHDL–C}/5.75 + {9.75 * TG}/{NonHDL–C} + 244/{HDL–C} − 2.95$
where:
$eLDL–TG$
$TG$
$HDL–C$
$NonHDL–C$
:
:
:
:
estimated triglyceride content in low-density lipoprotein (LDL) particles.
triglycerides measured
cholesterol content measured in high-density lipoprotein (HDL) particles.M
cholesterol content not contained in HDL particles. (Total cholesterol - HDL-C)
When we see a variable with high-variability in the denominator of a fraction, our spidey senses should start to tingle. Here we present a calculator to explore this equation further.
TG measured is
mg/dl
HDL-C measured is
mg/dl
ctrl-c (cmd-c for Mac) to copy:
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( HINT: Click-and-drag left-to-right on a chart to zoom in to a specific date range. Double-click on a chart to zoom back out. )